Reith et al. (1990): RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer.


1) Lang, D; Weiche, B; Timmerhaus, G; Richardt, S; Riano-Pachon, DM; Correa, LG; Reski, R; Mueller-Roeber, B; Rensing, SA. 2010. Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity. Genome Biol Evol. 2: 488-503 PubMed
2) Reith, W; Herrero-Sanchez, C; Kobr, M; Silacci, P; Berte, C; Barras, E; Fey, S; Mach, B. 1990. MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain. Genes Dev. 4(9):1528-40 PubMed


Name: RF-X
Class: TF
Number of species containing the TAP: 1
Number of available proteins: 3

The colour code corresponds to the rules for the domains:

should be contained
should not be contained

Domain rules:

(Domain names are clickable)

Phylogenetic tree for Archeaplastida:

No tree was calculated yet.

TAP distribution:

The following table shows the distribution of RF-X over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.

Minimum Maximum Average Median Standard deviation

List of species containing RF-X sorted by kingdomcladesupergrouporderfamily:

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expand kingdom Archaeplastida (3 proteins in 1 species)
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A list of species letter codes included in the protein names can be found here (opens in new tab).