Schiefthaler et al. (1999): Sexual reproduction is a salient aspect of plants, and elaborate structures, such as the flowers of angiosperms, have evolved that aid in this process. Within the flower the corresponding sex organs, the anther and the ovule, form the male and female sporangia, the pollen sac and the nucellus, respectively. However, despite their central role for sexual reproduction little is known about the mechanisms that control the establishment of these important structures. Here we present the identification and molecular characterization of the NOZZLE (NZZ) gene in the flowering plant Arabidopsis thaliana. In several nzz mutants the nucellus and the pollen sac fail to form. It indicates that NZZ plays an early and central role in the development of both types of sporangia and that the mechanisms controlling these processes share a crucial factor. In addition, NZZ may have an early function during male and female sporogenesis as well. The evolutionary aspects of these findings are discussed. NZZ encodes a putative protein of unknown function. However, based on sequence analysis we speculate that NZZ is a nuclear protein and possibly a transcription factor.


1) Schiefthaler, U; Balasubramanian, S; Sieber, P; Chevalier, D; Wisman, E; Schneitz, K. 1999. Molecular analysis of NOZZLE, a gene involved in pattern formation and early sporogenesis during sex organ development in Arabidopsis thaliana. Proc. Natl. Acad. Sci. U.S.A. 96(20):11664-9 PubMed
2) Wilson, ZA; Yang, C. 2004. Plant gametogenesis: conservation and contrasts in development. Reproduction 128(5):483-92 PubMed


Name: NZZ
Class: TF
Number of species containing the TAP: 34
Number of available proteins: 45

The colour code corresponds to the rules for the domains:

should be contained
should not be contained

Domain rules:

(Domain names are clickable)

Phylogenetic tree for Archeaplastida:

No tree was calculated yet.

TAP distribution:

The following table shows the distribution of NZZ over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.

Minimum Maximum Average Median Standard deviation

List of species containing NZZ sorted by kingdomcladesupergrouporderfamily:

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expand kingdom Archaeplastida (46 proteins in 34 species)
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A list of species letter codes included in the protein names can be found here (opens in new tab).