Lee et al. (1997): A temperature-sensitive mutation was obtained in Med6p, a component of the mediator complex from the yeast Saccharomyces cerevisiae. The mediator complex has been shown to enable transcriptional activation in vitro. This mutation in Med6p abolished activation of transcription from four of five inducible promoters tested in vivo. There was no effect, however, on uninduced transcription, transcription of constitutively expressed genes, or transcription by RNA polymerases I and III. Mediator-RNA polymerase II complex isolated from the mutant yeast strain was temperature sensitive for transcriptional activation in a reconstituted in vitro system due to a defect in initiation complex formation. A database search revealed the existence of MED6-related genes in humans and Caenorhabditis elegans, suggesting that the role of mediator in transcriptional activation is conserved throughout the evolution.


1) Kim, YJ; Björklund, S; Li, Y; Sayre, MH; Kornberg, RD. 1994. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 77(4):599-608 PubMed
2) Lee, YC; Min, S; Gim, BS; Kim, YJ. 1997. A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans. Mol. Cell. Biol. 17(8):4622-32 PubMed


Name: Med6
Class: TR
Number of species containing the TAP: 115
Number of available proteins: 160

The colour code corresponds to the rules for the domains:

should be contained
should not be contained

Domain rules:

(Domain names are clickable)

Phylogenetic tree for Archeaplastida:

No tree was calculated yet.

TAP distribution:

The following table shows the distribution of Med6 over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.

Minimum Maximum Average Median Standard deviation

List of species containing Med6 sorted by kingdomcladesupergrouporderfamily:

hide all | show all

expand kingdom Archaeplastida (171 proteins in 115 species)
select all | unselect | select genome only

A list of species letter codes included in the protein names can be found here (opens in new tab).