ARID
Description
| Kortschak et al. (2000): | Members of the recently discovered ARID (AT-rich interaction domain) family of DNA-binding proteins are found in fungi and invertebrate and vertebrate metazoans. ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. Although the specific roles of this domain and of ARID-containing proteins in transcriptional regulation are yet to be elucidated, they include both positive and negative transcriptional regulation and a likely involvement in the modification of chromatin structure. |
| Patsialou et al. (2005): | The ARID (A-T Rich Interaction Domain) is a helix-turn-helix motif-based DNA-binding domain, conserved in all eukaryotes and diagnostic of a family that includes 15 distinct human proteins with important roles in development, tissue-specific gene expression and proliferation control. Most ARID family members have not been characterized with respect to their DNA-binding behavior, but it is already apparent that not all ARIDs conform to the pattern of binding AT-rich sequences |
References:
| 1) | Kortschak, RD; Tucker, PW; Saint, R. 2000. ARID proteins come in from the desert. Trends Biochem. Sci. 25(6):294-9 PubMed |
| 2) | Patsialou, A; Wilsker, D; Moran, E. 2005. DNA-binding properties of ARID family proteins. Nucleic Acids Res. 33(1):66-80 PubMed |
| 3) | Wilsker, D; Patsialou, A; Dallas, PB; Moran, E. 2002. ARID proteins: a diverse family of DNA binding proteins implicated in the control of cell growth, differentiation, and development. Cell Growth Differ. 13(3):95-106 PubMed |
| 4) | Wilsker, D; Probst, L; Wain, HM; Maltais, L; Tucker, PW; Moran, E. 2005. Nomenclature of the ARID family of DNA-binding proteins. Genomics 86(2):242-51 PubMed |
Summary
| Name: | ARID |
|---|---|
| Class: | TF |
| Number of species containing the TAP: | 123 |
| Number of available proteins: | 1131 |
The colour code corresponds to the rules for the domains:
should be contained
should not be contained
should not be contained
Domain rules:
(Domain names are clickable)
Phylogenetic tree for Archeaplastida:
No tree was calculated yet.
TAP distribution:
The following table shows the distribution of ARID over all species included in TAPscan. The values for e.g. a specific kingdom are shown in the tree below if you expand the tree for that kingdom.
| Minimum | Maximum | Average | Median | Standard deviation |
|---|---|---|---|---|
| 0 | 40 | 9.26 | 9 | 6.73 |